![]() ![]() Consequently, metabolic acidosis occurred (Lac art) (from 2.4☐.6 to 5.7☑.8 mmol/L)( P<0.0001). RESULTS: The presence of obstructive shock could be evidenced by increased MPAP (from 17.8☓.5 to 41.7☓.3 mmHg) ( P<0.0001) and decreased cardiac output (from 4.9☑.0 to 2.7☑.0 L/min) ( P<0.003). The values of "near fatal" mean pulmonary arterial pressure (MPAP) were previously determined. ![]() METHODS: PE was induced in six pigs using autologous blood clots, and cardiorespiratory and gasometric records were performed before and after PE. OBJECTIVE: This study aimed to submit animals under spontaneous ventilation and without supplemental oxygen to PE. ![]() Studies which evaluated animals under conditions are lacking. Thus, under these conditions, measurements of hemodynamic, gasometric and capnographic variables contribute largely to a more specific comprehension of cardiopulmonary and gasometric alterations in the acute phase of the disease. Most patients with suspicion of PE enter the Emergency Services in spontaneous breathing and environmental air. ABSTRACT INTRODUCTION: Experimental studies on pulmonary embolism (PE) are usually performed under mechanical ventilation. ![]()
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